One more jQuery solution
For a single stylesheet with id "css" try this:
$('#css').replaceWith('<link id="css" rel="stylesheet" href="css/main.css?t=' + Date.now() + '"></link>');
Wrap it in a function that has global scrope and you can use it from the Developer Console in Chrome or Firebug in Firefox:
var reloadCSS = function() {
$('#css').replaceWith('<link id="css" rel="stylesheet" href="css/main.css?t=' + Date.now() + '"></link>');
};