I use this sometimes, for posting a localhost front-end site to a localhost back-end API (e.g. React to an old .NET API). I created a separate shortcut on my Windows 10 desktop, so that it never is used for normal browsing, only for debugging locally. I did the following:-
"[PATH_TO_CHROME]\chrome.exe" --disable-web-security
You will get a warning on load of this browser, that it is not secure, just take care with what you browser on it. I tend to rename this new shortcut on the desktop, something in capital, and move it away from my other icons, so it can't be confused for normal Chrome.
Hope this helps!