From SQL Server 2016 you can just use
DROP TABLE IF EXISTS ##CLIENTS_KEYWORD
On previous versions you can use
IF OBJECT_ID('tempdb..##CLIENTS_KEYWORD', 'U') IS NOT NULL
/*Then it exists*/
DROP TABLE ##CLIENTS_KEYWORD
CREATE TABLE ##CLIENTS_KEYWORD
(
client_id INT
)
You could also consider truncating the table instead rather than dropping and recreating.
IF OBJECT_ID('tempdb..##CLIENTS_KEYWORD', 'U') IS NOT NULL
TRUNCATE TABLE ##CLIENTS_KEYWORD
ELSE
CREATE TABLE ##CLIENTS_KEYWORD
(
client_id INT
)