use the "onmouseup" property with each option element. it's verbose, but should work. also, depending on what your function is actually doing, you could arrange things a little differently, assuming the number is important in the handler:
<select>
<option onmouseup="handler()" value="1">1</option> //get selected element in handler
<option onmouseup="handler(2)" value="2">2</option> //explicitly send the value as argument
<option onmouseup="handler(this.value)" value="3">3</option> //same as above, but using the element's value property and allowing for dynamic option value. you could also send "this.innerHTML" or "this.textContent" to the handler, making option value unnecessary
</select>