Bootstrap is an open-source CSS, JavaScript framework that was originally developed for twitter application by twitter's team of designers and developers. Then they released it for open-source. Being a longtime user of twitter bootstrap I find that its one of the best for designing mobile ready responsive websites. Many CSS and Javascript plugins are available for designing your website in no time. It's kind of rapid template design framework. Some people complain that the bootstrap CSS files are heavy and take time to load but these claims are made by lazy people. You don't have to keep the complete bootstrap.css in your website. You always have the option to remove the styles for components that you do not need for your website. For example, if you are only using basic components like forms and buttons then you can remove other components like accordions etc from the main CSS file. To start dabbling in bootstrap you can download the basic templates and components from getbootstrap site and let the magic happen.