A really simple implementation is:
out = "".join(c for c in asking if c not in ('!','.',':'))
and keep adding any other types of punctuation.
A more efficient way would be
import string
stringIn = "string.with.punctuation!"
out = stringIn.translate(stringIn.maketrans("",""), string.punctuation)
Edit: There is some more discussion on efficiency and other implementations here: Best way to strip punctuation from a string in Python