? "123,87,65".split(",").map(Number)
> [123, 87, 65]
Edit >>
Thanks to @NickN & @connexo remarks! A filter is applicable if you by eg. want to exclude any non-numeric values:
?", ,0,,6, 45,x78,94c".split(",").filter(x => x.trim().length && !isNaN(x)).map(Number)
> [0, 6, 45]