I think the easiest is to simply open the file in write mode and then close it. For example, if your file myfile.dat
contains:
"This is the original content"
Then you can simply write:
f = open('myfile.dat', 'w')
f.close()
This would erase all the content. Then you can write the new content to the file:
f = open('myfile.dat', 'w')
f.write('This is the new content!')
f.close()