Dim myRow() As Data.DataRow
myRow = dt.Select("MyColumnName = 'SomeColumnTitle'")
myRow(0)("SomeOtherColumnTitle") = strValue
Code above instantiates a DataRow. Where "dt" is a DataTable, you get a row by selecting any column (I know, sounds backwards). Then you can then set the value of whatever row you want (I chose the first row, or "myRow(0)"), for whatever column you want.