You can use the VBA string functions (as @onedaywhen points out in the comments, they are not really the VBA functions, but their equivalents from the MS Jet libraries. As far as function signatures go, they are called and work the same, even though the actual presence of MS Access is not required for them to be available.):
SELECT DISTINCT Left(LastName, 1)
FROM Authors;
SELECT DISTINCT Mid(LastName, 1, 1)
FROM Authors;