I've also seen this error in solutions where I have multiple projects (usually netTiers projects where I've updated one or more of the sub-projects to target the 4.0 framework). It can be problematic to remove. Oftentimes it can be resolved, however, by first fixing all other errors in sub-projects (eg, any missing references), individually rebuilding those sub-projects, then removing/adding back any references to those sub-projects in Visual Studio. Personally, I've had little luck resolving this error by cleaning the solution alone.