looks like you want to SUM all the columns (I'm not sure where "sum 3 columns" comes from), not just TotalHoursM, so try this:
SELECT
SUM( ISNULL(TotalHoursM ,0)
+ ISNULL(TotalHoursT ,0)
+ ISNULL(TotalHoursW ,0)
+ ISNULL(TotalHoursTH ,0)
+ ISNULL(TotalHoursF ,0)
) AS TOTAL
FROM LeaveRequest