I use this script in my extension "Grab Any Media" and work fine ( like youtube case )
var oldHref = document.location.href;
window.onload = function() {
var
bodyList = document.querySelector("body")
,observer = new MutationObserver(function(mutations) {
mutations.forEach(function(mutation) {
if (oldHref != document.location.href) {
oldHref = document.location.href;
/* Changed ! your code here */
}
});
});
var config = {
childList: true,
subtree: true
};
observer.observe(bodyList, config);
};