[html] Best way to change font colour halfway through paragraph?

<span> will allow you to style text, but it adds no semantic content.

As you're emphasizing some text, it sounds like you'd be better served by wrapping the text in <em></em> and using CSS to change the color of the <em> element. For example:

CSS

.description {
  color: #fff;
}

.description em {
  color: #ffa500;
}

Markup

<p class="description">Lorem ipsum dolor sit amet, consectetur 
adipiscing elit. Sed hendrerit mollis varius. Etiam ornare placerat 
massa, <em>eget vulputate tellus fermentum.</em></p>

In fact, I'd go to great pains to avoid the <span> element, as it's completely meaningless to everything that doesn't render your style sheet (bots, screen readers, luddites who disable styles, parsers, etc.) or renders it in unexpected ways (personal style sheets). In many ways, it's no better than using the <font> element.

_x000D_
_x000D_
.description {_x000D_
  color: #000;_x000D_
}_x000D_
_x000D_
.description em {_x000D_
  color: #ffa500;_x000D_
}
_x000D_
<p class="description">Lorem ipsum dolor sit amet, consectetur _x000D_
adipiscing elit. Sed hendrerit mollis varius. Etiam ornare placerat _x000D_
massa, <em>eget vulputate tellus fermentum.</em></p>
_x000D_
_x000D_
_x000D_