Now we've got CSS grid. Welcome to 2019.
/* Required */_x000D_
body {_x000D_
margin: 0;_x000D_
height: 100%;_x000D_
}_x000D_
_x000D_
#wrapper {_x000D_
height: 100vh;_x000D_
display: grid;_x000D_
grid-template-rows: 30px 1fr 30px;_x000D_
}_x000D_
_x000D_
#content {_x000D_
overflow-y: scroll;_x000D_
}_x000D_
_x000D_
/* Optional */_x000D_
#wrapper > * {_x000D_
padding: 5px;_x000D_
}_x000D_
_x000D_
#header {_x000D_
background-color: #ff0000ff;_x000D_
}_x000D_
_x000D_
#content {_x000D_
background-color: #00ff00ff;_x000D_
}_x000D_
_x000D_
#footer {_x000D_
background-color: #0000ffff;_x000D_
}
_x000D_
<body>_x000D_
<div id="wrapper">_x000D_
<div id="header">Header Content</div>_x000D_
<div id="content">_x000D_
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam, quis nostrud exercitation ullamco laboris nisi ut aliquip ex ea commodo consequat. Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum. Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam, quis nostrud exercitation ullamco laboris nisi ut aliquip ex ea commodo consequat. Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum._x000D_
</div>_x000D_
<div id="footer">Footer Content</div>_x000D_
</div>_x000D_
</body>
_x000D_