You will need some JavaScript to prevent cropping if you don't know the dimension of the image at the time you're writing the css.
<div id="container">
<img src="something.jpg" alt="" />
</div>
<script type="text/javascript">
(function() {
var img = document.getElementById('container').firstChild;
img.onload = function() {
if(img.height > img.width) {
img.height = '100%';
img.width = 'auto';
}
};
}());
</script>
#container {
width: 48px;
height: 48px;
}
#container img {
width: 100%;
}
If you use a JavaScript Library you might want to take advantage of it.