I have used it so far in two real projects very successfully. both are in the near real-time traffic information field (traffic as in cars on highways), distributed over several nodes, integrating messages between several parties, reliable backend systems. I'm not at liberty to give specifics on clients yet, when I do get the OK maybe it can be added as a reference.
Akka has really pulled through on those projects, even though we started when it was on version 0.7. (we are using scala by the way)
One of the big advantages is the ease at which you can compose a system out of actors and messages with almost no boilerplating, it scales extremely well without all the complexities of hand-rolled threading and you get asynchronous message passing between objects almost for free.
It is very good in modeling any type of asynchronous message handling. I would prefer to write any type of (web) services system in this style than any other style. (Have you ever tried to write an asynchronous web service (server side) with JAX-WS? that's a lot of plumbing). So I would say any system that does not want to hang on one of its components because everything is implicitly called using synchronous methods, and that one component is locking on something. It is very stable and the let-it-crash + supervisor solution to failure really works well. Everything is easy to setup programmatically and not hard to unit test.
Then there are the excellent add-on modules. The Camel module really plugs in well into Akka and enables such easy development of asynchronous services with configurable endpoints.
I'm very happy with the framework and it is becoming a defacto standard for the connected systems that we build.