you can write multiple lines in case of different minutes, for example you want to run at 10:01 AM and 2:30 PM
1 10 * * * php -f /var/www/package/index.php controller function
30 14 * * * php -f /var/www/package/index.php controller function
but the following is the best solution for running cron multiple times in a day as minutes are same, you can mention hours like 10,30
.
30 10,14 * * * php -f /var/www/package/index.php controller function