ActiveX resolved in Chrome!
Hello all this is not the solution but the successful workaround and I have implemented as well.
This required some implementation on client machine as well that why is most suitable for intranet environment and not recommended for public sites. Even though one can implement it for public sites as well the only problem is end user has to download/implement solution.
Lets understand the key problem
Chrome cannot communicate with ActiceX
Solution: Since Chorme cannot communicate with ActiveX but still it can communicate with the API hosted on the client machine. So develop API using .Net MVC or any other technology so that through Ajax call it can communicate with the API and API communicate with the ActiveX object situated on the client machine. Since API also resides in Client machine that why there is no problem in communication. This API works as mediator between Chrome browser and ActiveX.
During API implementation you might encounter CORS issues, Use JSONP to deal with it.
Pictorial view of the solution
Other solution : Use URI Scheme like MailTo: or MS-Word to deal with outlook and word application. If your requirement is different then you can implement your customized URI Scheme.