every text box has a validating and validated event you can use then as follows :-
Private Sub PriceTxt_Validating(ByVal sender As Object, ByVal e As System.ComponentModel.CancelEventArgs) Handles PriceTxt.Validating
If Not IsNumeric(PriceTxt.Text) Then
PriceTxt.BackColor = Color.Red
MsgBox("The Price Should Be Numeric Only , Enter Again", vbCritical)
PriceTxt.Text = ""
PriceTxt.BackColor = Color.White
End If
End Sub