I had to transfer texts from an Excel file to an xliff file. We had some texts that were originally in uppercase but those translators didn't use uppercase so I used notepad++ as intermediate to do the conversion.
Since I had the mouse in one hand (to mark in Excel and activate the different windows) I disliked the predefined shortcut (Ctrl+Shift+U) as "U" is too far away for my left hand. I first switched it to Ctrl+Shift+X which worked.
Then I realized, that you can create macros easily, so I recorded one doing:
That macro got assigned that very shortcut (Ctrl+Shift+X) and made my life easy :)