(MacOS) I got this issue after getting some malware that was forcing me to use WeKnow as a search engine. To fix this on MacOs I followed these steps
Go to System Preferences, then check if there's an icon named Profiles.
Remove AdminPrefs profile
Change default search engine settings, Restart Chrome
The above partially helped (I still had WeKnow as my home page). After that I followed these steps:
Type chrome://policy/ to see the policies. You cannot change them there
Copy paste this into your terminal
defaults write com.google.Chrome HomepageIsNewTabPage -bool false
defaults write com.google.Chrome NewTabPageLocation -string "https://www.google.com/"
defaults write com.google.Chrome HomepageLocation -string "https://www.google.com/"
defaults delete com.google.Chrome DefaultSearchProviderSearchURL
defaults delete com.google.Chrome DefaultSearchProviderNewTabURL
defaults delete com.google.Chrome DefaultSearchProviderName
I've also ran a scan of my system with Avast antivirus that has detected some malware