[visual-studio] How do I REALLY reset the Visual Studio window layout?

How about running the following from command line,

Devenv.exe /ResetSettings

You could also save those settings in to a file, like so,

Devenv.exe /ResetSettings "C:\My Files\MySettings.vssettings"

The /ResetSettings switch, Restores Visual Studio default settings. Optionally resets the settings to the specified .vssettings file.

MSDN link