[sql-server-2005] Using IF..ELSE in UPDATE (SQL server 2005 and/or ACCESS 2007)

this should work

update table_name
  set column_b = case
                  when column_a = 1 then 'Y'
                  else null
                 end,
  set column_c = case
                  when column_a = 2 then 'Y'
                  else null
                 end,
  set column_d = case
                  when column_a = 3 then 'Y'
                  else null
                 end
where
 conditions

the question is why would you want to do that...you may want to rethink the data model. you can replace null with whatever you want.