Just use TeX ! This works :
title(r"""\Huge{Big title !} \newline \tiny{Small subtitle !}""")
EDIT: To enable TeX processing, you need to add the "usetex = True" line to matplotlib parameters:
fig_size = [12.,7.5]
params = {'axes.labelsize': 8,
'text.fontsize': 6,
'legend.fontsize': 7,
'xtick.labelsize': 6,
'ytick.labelsize': 6,
'text.usetex': True, # <-- There
'figure.figsize': fig_size,
}
rcParams.update(params)
I guess you also need a working TeX distribution on your computer. All details are given at this page: