You would have to tune it according to your environment.
Sometimes it's more useful to increase the size of the backlog (acceptCount) instead of the maximum number of threads.
Say, instead of
<Connector ... maxThreads="500" acceptCount="50"
you use
<Connector ... maxThreads="300" acceptCount="150"
you can get much better performance in some cases, cause there would be less threads disputing the resources and the backlog queue would be consumed faster.
In any case, though, you have to do some benchmarks to really know what is best.