[css] Image Greyscale with CSS & re-color on mouse-over?

There are numerous methods of accomplishing this, which I'll detail with a few examples below.

Pure CSS (using only one colored image)

img.grayscale {
  filter: url("data:image/svg+xml;utf8,<svg xmlns=\'http://www.w3.org/2000/svg\'><filter id=\'grayscale\'><feColorMatrix type=\'matrix\' values=\'0.3333 0.3333 0.3333 0 0 0.3333 0.3333 0.3333 0 0 0.3333 0.3333 0.3333 0 0 0 0 0 1 0\'/></filter></svg>#grayscale"); /* Firefox 3.5+ */
  filter: gray; /* IE6-9 */
  -webkit-filter: grayscale(100%); /* Chrome 19+ & Safari 6+ */
}

img.grayscale:hover {
  filter: none;
  -webkit-filter: grayscale(0%);
}

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img.grayscale {_x000D_
  filter: url("data:image/svg+xml;utf8,<svg xmlns=\'http://www.w3.org/2000/svg\'><filter id=\'grayscale\'><feColorMatrix type=\'matrix\' values=\'0.3333 0.3333 0.3333 0 0 0.3333 0.3333 0.3333 0 0 0.3333 0.3333 0.3333 0 0 0 0 0 1 0\'/></filter></svg>#grayscale");_x000D_
  /* Firefox 3.5+, IE10 */_x000D_
  filter: gray;_x000D_
  /* IE6-9 */_x000D_
  -webkit-filter: grayscale(100%);_x000D_
  /* Chrome 19+ & Safari 6+ */_x000D_
  -webkit-transition: all .6s ease;_x000D_
  /* Fade to color for Chrome and Safari */_x000D_
  -webkit-backface-visibility: hidden;_x000D_
  /* Fix for transition flickering */_x000D_
}_x000D_
_x000D_
img.grayscale:hover {_x000D_
  filter: none;_x000D_
  -webkit-filter: grayscale(0%);_x000D_
}_x000D_
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svg {_x000D_
  background: url(http://4.bp.blogspot.com/-IzPWLqY4gJ0/T01CPzNb1KI/AAAAAAAACgA/_8uyj68QhFE/s400/a2cf7051-5952-4b39-aca3-4481976cb242.jpg);_x000D_
}_x000D_
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svg image {_x000D_
  transition: all .6s ease;_x000D_
}_x000D_
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svg image:hover {_x000D_
  opacity: 0;_x000D_
}
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<p>Firefox, Chrome, Safari, IE6-9</p>_x000D_
<img class="grayscale" src="http://4.bp.blogspot.com/-IzPWLqY4gJ0/T01CPzNb1KI/AAAAAAAACgA/_8uyj68QhFE/s1600/a2cf7051-5952-4b39-aca3-4481976cb242.jpg" width="400">_x000D_
<p>IE10 with inline SVG</p>_x000D_
<svg xmlns="http://www.w3.org/2000/svg" id="svgroot" viewBox="0 0 400 377" width="400" height="377">_x000D_
  <defs>_x000D_
     <filter id="filtersPicture">_x000D_
       <feComposite result="inputTo_38" in="SourceGraphic" in2="SourceGraphic" operator="arithmetic" k1="0" k2="1" k3="0" k4="0" />_x000D_
       <feColorMatrix id="filter_38" type="saturate" values="0" data-filterid="38" />_x000D_
    </filter>_x000D_
  </defs>_x000D_
  <image filter="url(&quot;#filtersPicture&quot;)" x="0" y="0" width="400" height="377" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="http://4.bp.blogspot.com/-IzPWLqY4gJ0/T01CPzNb1KI/AAAAAAAACgA/_8uyj68QhFE/s1600/a2cf7051-5952-4b39-aca3-4481976cb242.jpg" />_x000D_
   </svg>
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You can find an article related to this technique here.

Pure CSS (using a grayscale and colored images)

This approach requires two copies of an image: one in grayscale and the other in full color. Using the CSS :hover psuedoselector, you can update the background of your element to toggle between the two:

#yourimage { 
    background: url(../grayscale-image.png);
}
#yourImage:hover { 
    background: url(../color-image.png};
}

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#google {_x000D_
  background: url('http://www.google.com/logos/keystroke10-hp.png');_x000D_
  height: 95px;_x000D_
  width: 275px;_x000D_
  display: block;_x000D_
  /* Optional for a gradual animation effect */_x000D_
  transition: 0.5s;_x000D_
}_x000D_
_x000D_
#google:hover {_x000D_
  background: url('https://graphics217b.files.wordpress.com/2011/02/logo1w.png');_x000D_
}
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<a id='google' href='http://www.google.com'></a>
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This could also be accomplished by using a Javascript-based hover effect such as jQuery's hover() function in the same manner.

Consider a Third-Party Library

The desaturate library is a common library that allows you to easily switch between a grayscale version and full-colored version of a given element or image.