The recommended way to create random integers with NumPy these days is to use numpy.random.Generator.integers. (documentation)
import numpy as np
import pandas as pd
rng = np.random.default_rng()
df = pd.DataFrame(rng.integers(0, 100, size=(100, 4)), columns=list('ABCD'))
df
----------------------
A B C D
0 58 96 82 24
1 21 3 35 36
2 67 79 22 78
3 81 65 77 94
4 73 6 70 96
... ... ... ... ...
95 76 32 28 51
96 33 68 54 77
97 76 43 57 43
98 34 64 12 57
99 81 77 32 50
100 rows × 4 columns