[python] Plot smooth line with PyPlot

I presume you mean curve-fitting and not anti-aliasing from the context of your question. PyPlot doesn't have any built-in support for this, but you can easily implement some basic curve-fitting yourself, like the code seen here, or if you're using GuiQwt it has a curve fitting module. (You could probably also steal the code from SciPy to do this as well).

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